​MRI-based Stem Cell Tracking Biosensors/Regenerative Medicine

Ngen EJ, Wang L, Kato L, Krishnamarchary B, Zhu W, Gandhi N, Smith B, Armour M, Wong J, Gabrielson K, Artemov D. Imaging transplanted stem cells in real time using an MRI dual contrast method. Sci Rep. 2015, 5:13628. Abstract

Ngen EJ, Wang L, Gandhi N, Kata Y, Armour M, Wong J, Gabrielson K, Artemov D. A preclinical murine model for the early detection of radiation-induced brain injury using magnetic resonance imaging and behavioral tests for learning and memory with applications for the evaluation of possible stem cell imaging agents and therapies. J Neuro-Oncol. 2016, 128(2):225-33. Abstract

Ngen EJ and Artemov D. Advances in monitoring cell-based therapies with magnetic resonance imaging: Future perspectives. Int J Mol Sci. Special Issue: Advances in cell transplantation, 2017, 18 (1): 198. Abstract

Ngen EJ, Kato Y and Artemov D. Direct stem cell labeling to image the delivery, survival and migration of transplanted stem cells in real time using the MRI dual contrast stem cell labeling technique. CP Stem Cell Biol. 2017, 42, 5A.10.1–5A.10.19. Abstract

Ngen EJ, Walczak P, Bulte JWM, Gilad AA. Chapter 10: The evolution of chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) reporter genes and sensors: Opportunities and challenges. In chemical exchange saturation transfer magnetic resonance imaging: Advances and applications, 2017, [ISN9789814745703]. Abstract

MRI-Guided Drug/Nanoparticle Delivery and Imaging Responses to Therapy

Ngen EJ, Bar-Shir A, Jablonska A, Lui G, Song X, Ansari R, Bulte JWM, Janowski M, Pearl E, Walczak P, Gilad AA. Imaging the DNA alkylator melphalan by CEST MRI: An advanced approach to theranostics. Mol Pharm. 2016, 13(9):3043-53. Abstract

Ngen EJ, Azad BB, Bionapally S, Lisok A, Brummet M, Pomper MG, Banerjee SR. MRI assessment of prostate specific membrane antigen (PSMA) expression by a targeted magnetic nanocarrier: Potential for image-guided therapy. Mol Pharm. 2019, 16(5):2060-2068. Abstract

Ngen EJ, Chen Y, Azad BB, Bionapally S, Jacob D, Lisok A, Shen C, Hossain MS, Jin J, Bhujwalla ZM, Pomper MG, Banerjee SR. Prostate specific membrane antigen (PSMA)-targeted photodynamic therapy enhances the delivery of PSMA-targeted magnetic nanoparticles to PSMA expressing prostate tumors. Nanotheranostics. 2021, 5(2):182-196. Abstract

Hapuarachchige S, Kato Y, Ngen EJ, Smith B, Delannoy M, Artemov D. Non-temperature induced effects of magnetized iron oxide nanoparticles in alternating magnetic field in cancer cells. PLOSONE. 2016, 11(5): e0156294. Abstract

Ray SB, Ngen EJ, Rotz M, Lisok A, Kakkad S, Shah T, Artemov D, Meade TJ, Bhujwalla ZM, Pomper MG. Syntheses and evaluation of gadolinium-based magnetic resonance imaging contrast agents for molecular imaging of prostate-specific membrane antigen. Angew Chem Int Ed Engl. 2015, 54(37):10778-82. Abstract

Other Image-Guided Drug Delivery systems

Ngen EJ, Rajaputra P, You Y. Evaluation of delocalized lipophilic cationic dyes as delivery vehicles for photosensitizers to mitochondria. Bioorg Med Chem. 2009, 17(18):6631-6640. Abstract

Ngen EJ, Xiao L, Rajaputra P, Xingzhong Y, You Y. Enhanced singlet oxygen generation from a porphyrin-rhodamine B dyad by two-photon excitation through resonance energy transfer. Photochem Photobiol. 2013, 89(4):841–848. Abstract

Banerjee SR, Kumar V, Lisok A, Chen J, Minn I, Brummet M, Boinapally S, Cole M, Ngen EJ, Wharram B, Brayton C, Hobbs RF, Pomper MG. 177 Lu-labeled low-molecular-weight agents for PSMA-targeted radiopharmaceutical therapy. Eur J Nucl Med Mol Imaging. 2019, 46(12):2545-2557. Abstract

Ngen EJ, Daniels TS, Murthy RS, Detty MR, You Y. Core-modified porphyrins. Part 6: Effects of lipophilicity and core system on physicochemical and biological properties in vitro. Bioorg Med Chem. 2008, 16(6):3171-3183. Abstract

The Responsive Imaging BioSensors and BioEngineering Lab